Toxicological assessment of polyhexamethylene biguanide for water treatment

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Toxicological assessment of polyhexamethylene biguanide for water treatment

Polyhexamethylene biguanide (PHMB) is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. There are regulatory concerns with regard to its safety in humans for water treatment. We decided to assess the safety of this chemical in Sprag...

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Benefit of polyhexamethylene biguanide in Fusarium keratitis.

PURPOSE To report a series of 3 patients with soft contact lens-related Fusarium keratitis. Two of them were treated with the antiamoebic polyhexamethylene biguanide 0.02% (PHMB) in combination with antifungal drugs, and 1 patient was treated with PHMB as sole antifungal regimen. METHODS Chart review of 3 patients treated with PHMB in Fusarium keratitis. Two of them were refractory to the com...

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Evaluating a dressing impregnated with polyhexamethylene biguanide

Aims: To evaluate a new polyhexamethylene biguanide (PHMB) foam dressing for inclusion in the specialist dressing section of a trust’s wound management formulary. Methods: KendallTM AMD (Covidien) antimicrobial foam dressing’s use was reviewed through a retrospective evaluation of patients who had been treated with the dressing. Data was collected from the medical and nursing notes of 25 patien...

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Evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus.

IMPORTANCE Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs. OBJECTIVE To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs. DESIGN In vitro laboratory study. INTERVEN...

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Polyhexamethylene biguanide functionalized cationic silver nanoparticles for enhanced antimicrobial activity

Polyhexamethylene biguanide (PHMB), a broad spectrum disinfectant against many pathogens, was used as a stabilizing ligand for the synthesis of fairly uniform silver nanoparticles. The particles formed were characterized using UV-visible spectroscopy, FTIR, dynamic light scattering, electrophoretic mobility, and TEM to measure their morphology and surface chemistry. PHMB-functionalized silver n...

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ژورنال

عنوان ژورنال: Interdisciplinary Toxicology

سال: 2015

ISSN: 1337-9569

DOI: 10.1515/intox-2015-0029